Instituto de Óptica “Daza de Valdés”

Invited talk by Elena Redaelli on the topic “Exploring corneal biomechanics with computational simulations”.

Divulgación

    • It will be held next February 15 at 14:30

 

Madrid / 9 de February de 2024

Exploring corneal biomechanics with computational simulations

Elena Redaelli, MSCA, PhD Student.
PhD Student at the University of Zaragoza in the framework of the European project OBERON ITN Marie Skłodowska-Curie.

Understanding the mechanical properties of the cornea is of great importance in studying corneal pathologies and predicting refractive surgery outcomes. Non-Contact Tonometry (NCT) is a non-invasive diagnostic tool intended to characterize the corneal tissue response in vivo by applying a defined air-pulse. The development of a strong numerical tool capable of modeling the NCT, applied to different structural and anatomical configurations, provides the basis for determining the biomechanical properties of the corneal tissue in vivo. A high-fidelity finite-element model of a patient-specific 3D eye for in-silico NCT will be presented; a fluid-structure interaction (FSI) simulation is developed to virtually apply a defined air-pulse to a patient-specific eye model. Then, a Montecarlo simulation is performed varying both the parameters describing the mechanical behaviour of the corneal tissue and the intraocular pressure. Based on the results of the Montecarlo simulation, a deep learning-based methodology is proposed to predict, in real time, the patient-specific corneal deformation and subsequently estimate the mechanical properties of the corneal tissue in vivo.

Elena Redaelli is a PhD student at Zaragoza University in the framework of the OBERON ITN Marie Skłodowska-Curie European Project. She holds a Master’s degree in biomedical engineering from Politecnico di Milano. Elena worked as a Research Fellow at Wroclaw University of Science and Technology and at University of Bern. Her expertise lies in investigating the mechanical properties of soft tissues with a particular focus on corneal biomechanics using computational simulations and surrogate models. In 2021 she was awarded the Nellie Award in for her Master’s thesis.

Friday, February 15, 2024 2:30 pm
Conference Room, Instituto de Óptica (CSIC)
C/ Serrano, 121 28006 Madrid

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